With Dew Stats for .NET it's not difficult to do complex tasks. Doing multiple linear regression is a peace of cake:
tMtxMulLinReg1.Y.LoadFromFile("c:\temp\yvals.vec");
tMtxMulLinReg1.A.LoadFromFile("c:\temp\system.mtx");
tMtxMulLinReg1.Recalculate();
MtxVecEdit.ViewValues(tMtxMulLinReg1.RegressResult.B,"Regression coefficients",true,false,false);
Other things to try:
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